The Role and Efficacy of Fibrin Glue in Repair of Peripheral Nerves; Meta-Analysis Study

Document Type : Review Article

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Department of Plastic and Reconstructive Surgery, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Abstract

Background: Fibrin glue has gained popularity in the field of peripheral nerve surgery as a substitute for traditional microsurgical suture repair. Fibrin glue began to have benefits for nerve reconstruction in the form of technical simplicity, reduced tissue manipulation, and quicker procedure timeframes. Although fibrin glue appears to be a promising substitute for traditional microsurgical repair, additional knowledge regarding the results of nerve healing is crucial.
The aim of the work: This meta-analysis aimed to assess the technical efficiency and outcome of Fibrin glue in the repair of peripheral nerves.
Methods: Clarivate -Scopus, PubMed, Cochrane, and Rigster TCT listed papers were searched for literature. EKB was one of many search engines employed by this investigation to download articles from the previous year.
Results: Seven studies assessed sensory recovery and showed that there were insignificant differences between these studies as patients had excellent sensory recovery [p-value 0.0735]. Seven studies assessed motor recovery and showed that there were significant differences between these studies as patients had good motor recovery [p-value <0.0001].
Conclusion:  In this study, a complete assessment of the material on fibrin glue for peripheral nerve restoration is conducted. According to the study's findings, suture repairs and repairs using fibrin glue may both result in nerve regeneration, although repairs using fibrin glue take less time to complete.

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