@article { author = {Elsharkawy, Dina and El-khaleegy, Hany Abd Elhady and Mohamed, Saad and Mohamed, Gamal}, title = {Seroprotection Status of Hepatitis B Vaccine in Children with Type 1 Diabetes Mellitus}, journal = {International Journal of Medical Arts}, volume = {3}, number = {3}, pages = {1748-1753}, year = {2021}, publisher = {Al-Azhar University (Damietta), Faculty of Medicine}, issn = {2636-4174}, eissn = {2682-3780}, doi = {10.21608/ijma.2021.81707.1331}, abstract = {Background:"Type 1 diabetes mellitus [T1DM]" is the most common endocrine disease in the Pediatric population. It has been suggested that T1DM had inadequate immunological response to vaccines, including hepatitis B virus [HBV] vaccine.Aim of the Work:To evaluate the immunological status against HBV vaccine among children with T1DM, and assess various possible risk factors for immunity failure.Patients and Methods:A comparative cross-sectional study included 60 children [4-10 years] with T1DM [case group], and 60 healthy age- and sex-matched children [control group]. All included children had completed obligatory HBV vaccine. The evaluation of the immunological response was assessed through analysis of antibodies against HBV surface [HBsAB]. Seroprotection status to HBV vaccine was identified as plasma HBsAB of ≥ 10 mIU/ml. Results:The mean duration of T1DM was 2.03 ± 1.73 years. The frequency of immunity failure to HBV vaccine [non-responders; HBsAB < 10 mIU/ml] was 51.7% among the case group, and 28.3% among the control group [P = 0.009]. Risk factors for immunity failure, as evaluated by regression analysis, were older age [P=0.002], and longer duration of T1DM [P=0.023].Conclusion: Children with T1DM have a reduced level of HBV vaccine seroprotection when compared to the control group. Patients with older age and longer duration of T1DM showed a trend toward non-responding HbsAB titer. Long-term follow-up of responders is recommended to retest the level of immune response. }, keywords = {seroprotection,hepatitis B,vaccine,Type-1 Diabetes Mellitus}, url = {https://ijma.journals.ekb.eg/article_187697.html}, eprint = {https://ijma.journals.ekb.eg/article_187697_fc895f4c39c95df2dfdbc56f928fb724.pdf} }