TY - JOUR ID - 187835 TI - Ventricular Function and Pulmonary Artery Pressure in Children with Mild and Moderate Bronchial Asthma JO - International Journal of Medical Arts JA - IJMA LA - en SN - 2636-4174 AU - Alsayad, Tarek Kotb AU - Mohamed, Saad Ahmed AD - Department of Pediatrics, Pediatric Cardiology Division, Faculty of Medicine, Al-Azhar University, Egypt AD - Department of Pediatrics, Damietta Faculty of Medicine, Al-Azhar University, Egypt Y1 - 2021 PY - 2021 VL - 3 IS - 3 SP - 1754 EP - 1760 KW - bronchial asthma KW - children KW - Ventricular function KW - Tissue Doppler imaging KW - Pulmonary Artery Pressure DO - 10.21608/ijma.2021.187835 N2 - Background: Bronchial asthma is a chronic airway disease. Cardiac affection in children with bronchial asthma was reported mainly in cases with severe asthma and during acute exacerbations.Aim of the Work: To study cardiac affection in children with mild and moderate bronchial asthma using conventional and tissue Doppler imaging [TDI] echocardiography.Patients and Methods: This was a prospective case control study. Study involved 160 children aged 6-14 years old who were following in outpatient pediatric clinic, Al-Hussein hospital, Al-Azhar University, Cairo, Egypt, during the period from January 4, 2016, till February 15, 2017. All children underwent peak expiratory flow rate [PEFR] assessment. Echocardiography was done for all to assess systolic and diastolic functions of right ventricle [RV] and left ventricle [LV] using conventional and tissue Doppler imaging [TDI] echocardiography.Results: TDI parameters showed evidence of RV diastolic dysfunction in patients with moderate asthma in the form of significantly lower tricuspid valve [TV] e’ [12.1 ± 2.7 cm/s], lower TV e’/a’ ratio [1.28 ± 0.18], prolonged RV isovolumetric relaxation time [IVRT] [71.8 ± 2.4 ms], and higher RV myocardial performance index [0.49 ± 0.04] compared to control group.  Also, patients with mild asthma had impaired RV diastolic function in the form of significantly lower TV e’/a’ [1.51 ± 0.13] and longer RV IVRT [65 ± 2.9 ms] compared to control group. Pulmonary artery pressure was significantly elevated in moderate asthma group [18.4 ± 9.2 mmHg]. RV IVRT was the only parameter showing a significant negative correlation to PEFRConclusion: Pediatric patients with mild and moderate bronchial asthma may have RV diastolic dysfunction. TDI is a good screening tool to detect early changes in cardiac function in such patients. RV IVRT measured by TDI is a sensitive tool to detect early diastolic impairment.  UR - https://ijma.journals.ekb.eg/article_187835.html L1 - https://ijma.journals.ekb.eg/article_187835_415b275c985e08c48cdf69377d5d9b98.pdf ER -