Incidence of Nasal Polyps Recurrence Rate in Patients with Eosinophilic Esophagitis after Endoscopic Endonasal Surgery

Document Type : Original Article

Authors

1 Department of Otorhinolaryngology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

2 Department of Otorhinolaryngology, Faculty of Medicine, Al-Azhar University, Egypt

3 Department of Pathology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

4 Department of Hepatology and Gastroenterology, Asuit Faculty of Medicine, Al-Azhar University, Egypt

5 Department of Hepatology and Gastroenterology, Faculty of Medicine, Al-Azhar University, Egypt

Abstract

Background: Nasal polys [NPs] are frequently encountered inotorhinolaryngology practice. It had been proposed to share etiological origin with eosinophilic esophagitis [EOE]. However, there is not yet adequate estimations of this association and incidence of NPs recurrence after endonasal surgery in patients with EOE.    
Aim of the work: To evaluate incidence of recurrence of NPs after endoscopic endonasal surgery for patients with EOE.
Patients and Methods: 150 patients were included and divided into three groups: the control [CG] [50 patients indicated for gastroscopy]. The nasal polyp’s subgroups consisted of 100 patients and further subdivided into two groups according to result of nasal biopsy into two subgroups, eosinophilic nasal polyps [ENP] group IIA; non-eosinophilic nasal polyps [NENP] group IIB. In NPs subgroups, sinonasal outcome test [SNOT22] had been performed to measure the health status and quality of life in patients with NPs through questions relating to their symptoms. The recurrence of nasal polyps were investigated after endoscopic sinus surgery and during follow up and outcome had been compared between groups.
Results: 22% suffered polyp recurrence after surgery during the follow-up period. Patients with EOE had a significantly higher recurrence rate of nasal polyps [100%] in comparison to 16.4% in EOE patients. These results indicate that, mucosal eosinophilia is a determinant factor in the recurrence of nasal polyps. Hence in patients with EOE [had mucosal eosinophilia] who underwent endonasal surgery, the recurrence of nasal polyps should be highly expected.
Conclusion: Mucosal eosinophilia in patients with EOE, and ENP are a more important prognostic factor in recurrence of nasal polyps.

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