Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo
Background: Many treatment options were used for Vitiligo. But there is no consensus on the precise treatment modality. Aim of the work: The study aimed to assess and compare the efficacy of microneedling combined with trichloracetic acid [TCA] versus micro-needling with tacrolimus in the treatment of Vitiligo, Patients and Methods: 60 Vitiligo were included and classified into two equal groups. Group [A] included 30 patients who received micro-needling with dermapen then tacrolimus 0.03 ointments every two weeks for six sessions. Group B included thirty patients who received micro-needling with dermapen then TCA 25% every two weeks for six sessions. The outcome was documented. Results: The repigmentation was slightly higher in TCA-treated patches than with tacrolimus. Excellent response in repigmentation occurred in 43.3%of TCA patches. In contrast, in 16.7% of tacrolimus-treated patches, Good improvement occurred in13.3% of TCA-treated patches while 23.3% of tacrolimus-treated patches. Moderate improvement occurred in10.0% TCA -treated patches while 30.0% of tacrolimus-treated patches, mild improvement occurred in 13.3% of TCA -treated patches. In comparison, only in 16.7% of tacrolimus-treated patches, However, there was a great difference between the two drugs regarding erythema, inflammation, and exfoliations, which occurred mainly with TCA. Conclusion: The mix of microneedling with either TCA 25% or tacrolimus is effective and safe in treating Vitiligo. However, TCA achieved a slightly increased percentage of repigmentation than tacrolimus.
Elnokaly, R., SayedAhmed, O., & Mohamed, H. (2021). Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo. International Journal of Medical Arts, 3(2), 1188-1194. doi: 10.21608/ijma.2021.48137.1205
MLA
Rofaida Mohamed Elnokaly; Osama Magdy Elshahat SayedAhmed; Hassan Abou Khodair Mohamed. "Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo", International Journal of Medical Arts, 3, 2, 2021, 1188-1194. doi: 10.21608/ijma.2021.48137.1205
HARVARD
Elnokaly, R., SayedAhmed, O., Mohamed, H. (2021). 'Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo', International Journal of Medical Arts, 3(2), pp. 1188-1194. doi: 10.21608/ijma.2021.48137.1205
VANCOUVER
Elnokaly, R., SayedAhmed, O., Mohamed, H. Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo. International Journal of Medical Arts, 2021; 3(2): 1188-1194. doi: 10.21608/ijma.2021.48137.1205
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