Oral Isotretinoin in the Treatment of Recalcitrant Molluscum Contagiosum in Children

Document Type : Original Article

Authors

1 Department of Dermatology, Venereology and Andrology, Dermatology and Leprosy Hospital in Damietta, Ministry of Health, Egypt

2 Department of Dermatology, Venereology and Andrology, Al-Azhar Faculty of Medicine, Damietta, Egypt

10.21608/ijma.2021.71160.1293

Abstract

Background:Recalcitrant molluscum contagiosum in children has been treated with many destructive procedures with a high recurrence rate, alternative treatments would be desirable in pediatric patients. Oral isotretinoin has been used to treat viral warts successfully in children.
Aim of the work: Our aim in this study wasto investigate the influence of oral isotretinoin in MC patients.
 Methods: Twenty children less than 18 years, with recalcitrant molluscum contagiosum were enrolled in this study, the treatment protocol was oral isotretinoin [0.5mg/kg] daily until complete clearance [maximum duration 3 months]. Patients were evaluated clinically and photographically every two weeks to assess the response to treatment and to report side effects of therapy. Patients with complete response were followed up monthly for three months to record the recurrence rate. Lipid profile [Triglycerides, cholesterol, LDL and HDL] and liver function tests [SGOT and SGPT] were performed before treatment and every 4 weeks during the treatment period.
Results:Mean age of participants was 12.90 ± 2.64 years, 80% of them were more than 10 years old, [65%] were male, and the mean weight of studied cases was 49.10 ± 15.33 kg. The face was most common affected site in most cases [45%]. The mean lesion size was 2.63 ± 1.11 mm, and mean number of molluscum lesions of 23.55 ± 12.85.  As regarding to recurrence rate, 93.8% of cases who had complete response were still free at the end of 3 months follow up and only 6.3% had recurrence. Reported side effects were dry lips in all participants, 55% had a dry skin and 30% had a dry nose.
Conclusion: Oral isotretinoin therapy improves recalcitrant MC lesions in children, which maycontribute to its therapeutic efficacy.  

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