A Cross-sectional Study on the Evaluation of Thyroid Hormone Levels and Lipid Profile in Chronic Kidney Disease Patients and to Establish their Correlation with Disease Severity

Document Type : Original Article

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Department of Medicine, RDGMC, Ujjain, Madhya Pradesh, India

Abstract

Background: Chronic kidney disease [CKD] is linked to poor kidney function and a persistent decrease in glomerular filtration rate. Almost no lipid profile anomalies in CKD to patho-physiologically notable variations in lipid profile in patients with CKD such as raised triglycerides and low high-density lipoprotein levels have been reported in Indian research proving the pathophysiological link of CKD with Lipid profile.
Aim of the Study: To estimate the thyroid hormone level and lipid profile in chronic kidney disease patients and to establish a correlation between them.
Patients and Methods: CKD patients with moderate to severe disease, irrespective of gender, within the age groups 20-90 years were included in the study. Moderate CKD [stage 3] is defined as an estimated glomerular filtration rate [eGFR] of 30-60 ml/min, whereas severe CKD [stages 4 and 5] is defined as an eGFR of less than 30 ml/min & patients on maintenance hemodialysis were included. Blood urea, Serum creatinine, Lipid profile, TSH, total T3, and total T4 values of subjects were obtained and analysed. CKD staging was done on eGFR.
Results: Our study included 123 CKD patients who met the criteria for the disease. 95 % of the patients had high TSH levels, 48% had low T3 levels, and 95 % had low T4 levels. Out of 123 patients, 87% [N=108] patients had deranged lipid profiles.
Conclusion: The study concluded that there is statistically significant association between Chronic Kidney disease and deranged lipid and thyroid profiles and hypothyroid state.

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