Role of Vitamin D Deficiency and Radiological Assessment in The Diagnosis of Allergic Rhinitis in Children

Abdel Alazim, Hebatullah Ali Zain Elabdeen; Abdelaziz, Seham Nabil Ramdan; Tahoun, Sara A.; Sonbol, Marwa Mostafa Fadel Mohamed

doi:10.21608/ijma.2022.174014.1551

Role of Vitamin D Deficiency and Radiological Assessment in The Diagnosis of Allergic Rhinitis in Children

Document Type : Original Article

Authors

¹ Department of Otorhinolaryngology, Faculty of Medicine [for girls], Al-Azhar University, Cairo, Egypt

² Department of Pediatrics, Faculty of Medicine [for girls], Al-Azhar University, Cairo, Egypt

³ Department of Clinical Pathology, Faculty of Medicine [for girls], Al-Azhar University, Cairo, Egypt

⁴ Department of Radio-diagnosis, Faculty of Medicine [for girls], Al-Azhar University, Cairo, Egypt

10.21608/ijma.2022.174014.1551

Abstract

Objective: Determining whether there is any correlation between vitamin D status and the intensity of the allergic rhinitis [AR]. This study examined the serum vitamin D concentrations in a group of pediatric with AR.
Patients and methods: In this research, 150 children with AR and 150 unaffected kids were enrolled. Each participant's serum concentrations of vitamin D 25[OH]D and 1,25[OH]2D were observed. The relationships between the clinical features of AR and vitamin D status have been demonstrated. The occurrence of an allergy reaction, a positive multiple allergen simultaneously testing, and a serological total immunoglobulin E level [≥ 100 kU/L] were used to diagnose allergic rhinitis. For both groups, the smallest cross-sectional area on acoustic rhinometry was investigated. CT scanning nose and paranasal sinuses were used to quantify the hypertrophied inferior nasal turbinate, sinuses and nasal cavity.
Results: Participants in the AR group displayed significantly decreased serum concentrations of 25[OH]D, 1,25[OH]2D, and calcium than controls [p <0.0001, p<0.001, and p < 0.0001, accordingly]. Additionally, individuals with moderate to severe AR had considerably lower average 25-OHD3 concentrations than others with mild AR [p<0.001]. In the AR group, a substantial negative relationship between average 25[OH]D concentrations were observed, total nasal symptoms rating, and total immunoglobulin E levels [r =-0.71, p =0.003, and r =-0.26, p =0.032].
Conclusion: As contrasted to the healthy participants, vitamin D insufficiency is a frequently occurrence amongst pediatric with AR. A substantial negative correlation between concentrations of vitamin D and the intensity of AR illness has been demonstrated.

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