Assessment of the Outcome of Stereotactic Unilateral Pallidotomy Surgery for Parkinson’s Disease

Document Type : Original Article

Authors

1 Department of Neurosurgery, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt

2 Department of Neurosurgery, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Abstract

Background: The principal type of Parkinsonism that occurs most often is Parkinson's disease [PD]. Pallidotomies decrease stiffness, tremor, and dyskinesias, however bilateral pallidotomies have a higher risk of consequences, including cognitive decline and dysarthrias.   
Aim of the Work: The clinical motor results of stereotactic pallidotomy procedures for Parkinson's disease and possible complications.
Patients and Methods: This research, which included 20 patients who received stereotactic unilateral pallidotomies for Parkinson's disease, was carried out in both a retrospective and prospective manner at the Department of Neurosurgery Al-Azhar University Hospitals. 
Results: This study demonstrated a comparison of Unified Parkinson's Disease Rating Scale [UPDRS] 3 [motor symptoms]. There was very statistical substantial [p-value < 0.001] decreased UPDRS 3 post-operative [33.0 ± 8.5] and 6 months post-operative [33.3 ± 9.02] when compared with pre-operative UPDRS 3 [45.8 ± 10.4]. As regards Post-Hoc test for multiple comparisons and UPDRS 3, there was very statistical substantial variation [p-value < 0.001] between pre-operative and post-operative UPDRS 3 and 6 months post-operative UPDRS. As regards comparison of activity daily life [ADL] [UPDRS 2], there was statistically substantial [p-value = 0.009], decreased ADL [UPDRS 2] post-operative [25.6 ± 6.02] and 6 months post-operative [24.7 ± 5.5] when compared with pre-operative ADL [UPDRS 2] [31.8 ± 7.7]. As regards Post-Hoc test for multiple comparisons and ADL [UPDRS 2], there was statistically substantial variation [p-value = 0.004] between pre-operative and post-operative ADL [UPDRS 2]. Considering comparison of dyskinesia, there was highly statistical substantial variation [p-value < 0.001] of dyskinesia.
Conclusion: Stereotactic Unilateral pallidotomy for Parkinson’s Disease had good effect on improving motor functions assessed by Unified Parkinson's disease rating scale especially the motor functions in follow up after operation with little prevalence of complications.

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