Platelet Indices as Predictors of Diabetic Kidney Disease in Type 2 Diabetes Mellitus

Document Type : Original Article

Authors

1 Department of Internal Medicine, National Institute of Diabetes and Endocrinology, Cairo, Egypt.

2 Department of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

3 Department of Clinical Pathology, National Institute of Diabetes and Endocrinology, Cairo, Egypt.

Abstract

Background: Type 2 diabetes (T2D) is characterized as a complicated and varied group of metabolic conditions. The disorder's defining feature is increased blood sugar level brought on by a malfunction in insulin action and/or secretion.
Aim of the Work: To evaluate Platelet indices as predictive biomarkers for diabetic nephropathy in diabetes type 2.
Patients and Methods: This study included 60 diabetic subjects and 30 healthy subjects as control group. Participants were classified into three groups: Group I: 30 diabetic subjects without nephropathy. Group II: 30 diabetic subjects with nephropathy. Group III: 30 healthy non diabetic subjects.
Results: Our study showed that there was statistically significant increase in platelet distribution width (PDW) and mean platelet volume (MPV) among diabetic nephropathy participants than in non-diabetic nephropathy subjects. Also, our study showed that obesity had negative impact on renal functions in diabetic patients, we observed statistically significant increased body mass index (BMI) in diabetic patients with and without nephropathy when compared with BMI of non-diabetic patients. We noted that diabetic nephropathy is considerably more likely in people with poor glycemic control, there was statistically significant increased glycated hemoglobin (HbA1c) in diabetic nephropathy when compared to those without diabetic nephropathy.
Conclusion: Our study showed that patients with diabetic nephropathy (DN) have higher levels of platelet indices like PDW and MPV when compared to those without diabetic nephropathy. Hence PDW and MPV can be used as inexpensive and simple biomarker of diabetic nephropathy.

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