Assessment of Lisinopril Anti-Inflammatory Effect in Albino Rats

Document Type : Original Article

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Department of Pharmacology, Faculty of Medicine [for girls], Al-Azhar University, Cairo, Egypt

Abstract

Background: Renin-angiotensin-aldosterone system produces the hormone angiotensin II (Ang II). Vascular tension is regulated, pro-inflammatory cytokines are released, nuclear factor kappa B is activated, oxidative stress is increased, and angiotensin-II serves as an inflammatory mediator. Angiotensin-converted enzymes (ACE) inhibitor lisinopril works by preventing ACE, which lowers angiotensinogen II production. The purpose of the current study was to assess lisinopril's anti-inflammatory effect in albino rats
Aim of the work: To assess Lisinopril’s anti-inflammatory effect in albino rats at different hour in carrageenan induced paw oedema using Vernier caliper as well as to evaluate the mean granuloma weight in Lisinopril and diclophenac potassium as compared to control group.
Materials and Methods: From a centralized animals’ facility, 21 Wistar albino rats of both sexes, weighed between 150 and 200 g, were randomly chosen and categorized into three categories. The experimental group obtained lisinopril (1.8 mg/kg) orally for a period of six days, whereas the typical group got diclophenac potassium 5 mg/kg and the control group obtained standard saline 25 ml/kg. The rats underwent an experiment of cotton pellets-induced granuloma and carrageenan-induced paws oedema.
Results: As contrasted with controls and in cases of cotton pellets and carrageenan-induced granuloma, Lisinopril dramatically reduced the average paws oedema. Contrary to the control, Lisinopril lowered the average granuloma weight.
Conclusion: When administered orally to albino rats for a period of six days in a row, Lisinopril shown anti-inflammatory properties in an experiment for granuloma and paws oedema caused by cotton pellets and carrageenan.

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