Assessment of Autotaxin, Oxidized LDL and β2-Microglobulin in Patients with Diabetic Nephropathy

Document Type : Original Article

Authors

1 Department of Medical Biochemistry, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

2 Department of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Abstract

Background: Diabetes mellitus [DM] is a metabolic condition characterized by hyperglycemia caused by deficiencies in insulin action or secretion or both. Diabetes' persistent hyperglycemia is linked to long-term organ failure, including kidney loss of functions, leading to diabetic nephropathy [DN].
Aim of the work: This study aims to assess the value of serum autotaxin [ATX], oxidized LDL [ox LDL], and β2-microglobulin [β2M] as biomarkers for DN patients.
Patients and Methods: This cross-sectional study included 100 subjects divided into three groups. Group 1; control group [20 healthy subjects]. Patients were subdivided into two groups, group 2 [40 patients diagnosed with DN stages Ⅰ, Ⅱ, and Ⅲ], and group 3 which involved 40 patients diagnosed with DN stages Ⅳ and Ⅴ.
Results: As regards the ATX, it was significantly higher in group 3 than in group 1 and group 2 with a statistically significant difference between every 2 groups [P value > 0.05 for all]. In terms of Ox LDL and β2M, the difference between the three groups was significant statistically [P value = 0.005, and 0.002 respectively], however the difference between group 2 and group 3 was not significant [P value = 0.44, and 0.98 respectively].
Conclusion: Serum autotaxin, ox LDL, and β2M can be used as diagnostic noninvasive biomarkers in DN.

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