Effect of Remote Ischemic Preconditioning on Patient Survival and End Organ Injury During Elective Open Abdominal Aortic Surgery Repair: A Randomized Controlled Trial

Document Type : Original Article

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Department of Anesthesia and Surgical Intensive Care, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Abstract

Background: Ischemic preconditioning is natural cytoprotective mechanism that can potentially protect end organs from ischemia. In examined instances having major vascular surgery, remote ischemia preconditioning provides straight-forward technique with the ability to set up widespread and systemic protection from significant organ harm. Thus, we have been required to assess clinical usage of remote preconditioning in preparing myocardial and renal protection after elective open Abdominal Aortic Aneurysm [AAA] repair in randomized trial.
Aim of the work: The aim of this research had been to examine potential of remote ischemic preconditioning on myocardial and renal protection and patient survival after elective open AAA repair.
Patients and Methods: This randomized double blinded clinical trial comparing AAA repair with remote ischemic preconditioning versus conventional AAA repair [control] was done in cardiothoracic and vascular surgery center Mansoura University from October 2022 to May 2023 after approval from institutional review board of Mansoura faculty of Medicine with obtaining a written informed consent from all studied cases.
Results: There had been statistically significant variation among studied groups as regard 30-day mortality.
Conclusion: Remote ischemic preconditioning improves mortality rate after elective open abdominal aortic surgery repair.

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