Value of Platelet Indices in Evaluation of Varicocele Patients and Its Associated Abnormal Semen Parameters: A Cross Sectional Study

Document Type : Original Article

Authors

1 Department of Dermatology, Venereology and Andrology, The Egyptian Ministry of Health, Cairo, Egypt

2 Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

3 Department of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Abstract

Background: Varicocele is present in up to 19­–41% of men with primary infertility and 80% of men with secondary infertility. Varicocele is associated with abnormal semen parameters. The role of platelet indices [PIs] in many vascular diseases, including varicocele, has been widely studied.
Aim of the Study: The aim of this study was to evaluate the platelet indices in varicocele patients and its value in association with abnormal semen parameters.
Patients and Methods: A cross sectional study was conducted on 122 male patients with varicocele, recruited from Dermatology, Venereology & Andrology Outpatient Clinics in Al-Azhar University Hospitals, Cairo, Egypt. The patients were classified into two groups [61 patients with varicocele associated with normal semen parameters and 61 patients with varicocele associated with abnormal semen parameters]. All patients were subjected to history taking, general and genital examination, complete blood count [CBC] and Scrotal Doppler Ultrasound. PIs were then compared between the two groups by their characteristics and grade of varicocele using appropriate statistical tests.
Results: Of the studied platelet indices, the mean platelet volume [MPV] and plateletcrit [PCT] were significantly higher in varicocele group associated with abnormal semen parameters compared to varicocele group associated with normal semen parameters [9.5 ± 1.4 vs. to 7.9 ± 0.98; and 0.22 ± 0.05 vs. 0.18 ± 0.04]. In the varicocele group associated with abnormal semen parameters, the mean PCT and platelet distribution width [PDW] were significantly higher in the studied varicocele grades II and III compared to grade I. A significant moderate positive correlation was found between MPV and PCT and the number of sperms in the varicocele group associated with abnormal semen parameters.
Conclusion: The study findings indicating that MPV and PCT were significantly higher in Varicocele patients with abnormal semen parameters than in normospermic varicocele patients.

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