Efficacy of Topical Latanoprost Versus Topical Minoxidil In the Treatment of Alopecia Areata: Clinical and Dermoscopic Study

Document Type : Original Article

Authors

1 Department of Histology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt

2 Department of Dermatology, Venereology and Andrology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt

3 Department of Pathology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt

Abstract

Background: The non-scarring hair loss caused by alopecia areata is a result of a persistent inflammatory condition of unclear origin. As of right moment, alopecia areata has no suggested course of therapy.
Aim of the work: The aim of this research was to assess the efficacy of topical minoxidil and topical latanoprost in managing alopecia areata.
Patients and Methods: A total of 40 individuals diagnosed with alopecia areata were randomly divided into two treatment groups. Specifically, Group A comprised 20 patients who were administered topical latanoprost solution at a concentration of 0.1%, whereas twenty patients in Group B received topical 5% minoxidil. Clinical and dermoscopic imaging were utilized to evaluate the response to therapy.
Results: Both treatment approaches resulted in a notable enhancement in all dermoscopic observations associated with alopecia areata when analyzing pre- and post-therapy results. The latanoprost group exhibited notably greater effectiveness compared to the minoxidil group. The minor side effects of both treatment plans were erythema and itching and no major side effects.
Conclusion: Based on pre- and post-treatment the dermoscopic findings in alopecia areata patients showed dramatically improvement by either 0.1% Latanoprost or topical 5% Minoxidil.

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