Effect of Oral Exposure to Bisphenol A on the Liver and Kidney of Adult Male Albino Rats

Document Type : Original Article


1 Department of Physiology, Damietta Faculty of Medicine, Al-Azhar University, Egypt

2 Department of Forensic Medicine and Clinical Toxicology, Damietta Faculty of Medicine, Al-Azhar University, Egypt


Background: The organic composite of two phenolic neighbors [BPA] is Bisphenol A [BPA]. It is also commonly called propane 2,2 bis[4-hydroxyphenyl]. BPA is a voluminous industrial chemical used to manufacture epoxy resins and plastics.
 Aim of the work: Evaluation of the effect of oral Bisphenol A on the liver and kidney of adult male albino rats.
 Materials and Methods: Forty adult male albino rats [local strain] were divided into four groups [each 10 rats]. First is the control group, second is the low does BPA, third is moderate does BPA, and four is the high does BPA. The duration of exposure extended to 30 days. Then, blood samples have been collected for the measurement of serum aspartate aminotransferase [AST], serum alanine aminotransferase [ALT], blood urea, serum creatinine, superoxide dismutase [SOD], catalase, and glutathione. Also, hepatic and renal tissue samples were prepared for histopathological study.
Results: Oral administration of BPA in a dose of 50, 100, and 150 Mg/kg/day for 30 days led to a significant increase in the blood levels of ALT, AST, urea, and creatinine associated with a significant reduction in the blood levels of superoxide dismutase, Glutathione peroxidase, and catalase. There were few vacuolations of hepatocytes and congested blood vessels of the liver that were associated with changes in the kidney [narrow cortex, dilated tubules, and hypercellular glomeruli].
Conclusion: Bisphenol A oral exposure for 30 consecutive days is associated with several changes in biochemical parameters that indicate liver and kidney injury.


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